《英文msh词典》dsRNA-Activated Inhibitor
[入口词] dsRNA-Activated Inhibitor
[主题词] eIF-2 Kinase
[英文释义] A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP,EUKARYOTIC INITIATION FACTOR-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2,leading to the inhibition of protein synthesis.