《英文msh词典》Alexanders Disease
[入口词] Alexanders Disease
[主题词] Alexander Disease
[英文释义] A rare inherited disorder of myelin formation. Alexander disease is a progressive leukencephalopathy whose hallmark is the widespread accumulation of cytoplasmic inclusions called Rosenthal fibers. The fibers contain GLIAL FIBRILLARY ACIDIC PROTEIN in association with ALPHA-CRYSTALLIN B CHAIN. Rosenthal fibers are found predominantly in ASTROCYTES located in the subependymal,subpial,and periventricular areas of the BRAIN.