| 单词 | Alexanders Disease |
| 释义 | Alexanders Disease《英文msh词典》Alexanders Disease [入口词] Alexanders Disease [主题词] Alexander Disease [英文释义] A rare inherited disorder of myelin formation. Alexander disease is a progressive leukencephalopathy whose hallmark is the widespread accumulation of cytoplasmic inclusions called Rosenthal fibers. The fibers contain GLIAL FIBRILLARY ACIDIC PROTEIN in association with ALPHA-CRYSTALLIN B CHAIN. Rosenthal fibers are found predominantly in ASTROCYTES located in the subependymal,subpial,and periventricular areas of the BRAIN. |
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