《英文msh词典》Gene Silencing,Posttranscriptional
[入口词] Gene Silencing,Posttranscriptional
[主题词] RNA Interference
[英文释义] A gene silencing phenomenon whereby specific dsRNAs (RNA,DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA,MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX (RISC). DNA METHYLATION may also be triggered during this process.