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单词 Heterozygosity,Loss of
释义

Heterozygosity,Loss of


《英文msh词典》Heterozygosity,Loss of
[同义词] Heterozygosity,Loss of
[主题词] Loss of Heterozygosity
[中文释义] 杂合性,丢失
[英文释义] The loss of one allele at a specific locus,caused by a deletion mutation; or loss of a chromosome from a chromosome pair,resulting in abnormal hemizygosity. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted. When this occurs at a tumor suppressor gene locus where one of the alleles is already abnormal,it can result in neoplastic transformation (CELL TRANSFORMATION,NEOPLASTIC).
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