| 单词 | MDR Genes |
| 释义 | MDR Genes《英文msh词典》MDR Genes [同义词] MDR Genes [主题词] Genes,MDR [中文释义] MDR基因 [英文释义] Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian P-glycoproteins are encoded by small MDR gene familes. The human multidrug resistance 1 (MDR1) gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (Biochem Biophys Res Commun 1994;199(3):1428-35; Cancer Res 1994:54(6):1536-41) |
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