单词 | MK733 |
释义 | MK733《英文MSH词典》MK733 [入口词] MK733 [主题词] Simvastatin [药动学] Hydroxymethylglutaryl-CoA Reductase Inhibitors [英文释义] A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES),which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS,it increases breakdown of LDL-cholesterol (LIPOPROTEINS,LDL CHOLESTEROL). |
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