单词 | Modulators,GABAergic |
释义 | Modulators,GABAergic《英文msh词典》Modulators,GABAergic [入口词] Modulators,GABAergic [主题词] GABA Modulators [英文释义] Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS,GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses,but they are not included here. |
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