| 单词 | Oncogene Products v erbA |
| 释义 | Oncogene Products v erbA《英文msh词典》Oncogene Products v erbA [入口词] Oncogene Products v erbA [主题词] Oncogene Proteins v-erbA [英文释义] Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA,the thyroid hormone receptor (RECEPTORS,THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA,inducing transformation by disinhibiting proliferation. |
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