| 单词 | Oncogene Protein p190(bcr-abl) |
| 释义 | Oncogene Protein p190(bcr-abl)《英文msh词典》Oncogene Protein p190(bcr-abl) [同义词] Oncogene Protein p190(bcr-abl) [主题词] Fusion Proteins,bcr-abl [英文释义] Translation products of a fusion mRNA derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in Abelson murine leukemia virus. |
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