| 单词 | 2',3' Dideoxyadenosine |
| 释义 | 2',3' Dideoxyadenosine《英文msh词典》2',3' Dideoxyadenosine [入口词] 2',3' Dideoxyadenosine [主题词] Dideoxyadenosine [药动学] Antiviral Agents [英文释义] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication,acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo,dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate,the putative active metabolite. |
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