| 单词 | Autoimmune Neuropathy,Experimental |
| 释义 | Autoimmune Neuropathy,Experimental《英文msh词典》Autoimmune Neuropathy,Experimental [入口词] Autoimmune Neuropathy,Experimental [主题词] Neuritis,Experimental Allergic [英文释义] An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol,animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system,similar to that seen in the Guillaine-Barre syndrome. (From Adams et al.,Principles of Neurology,6th ed,p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52) |
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