| 单词 | Poly(A) Binding Protein,Nuclear 1 |
| 释义 | Poly(A) Binding Protein,Nuclear 1《英文msh词典》Poly(A) Binding Protein,Nuclear 1 [入口词] Poly(A) Binding Protein,Nuclear 1 [主题词] Poly(A)-Binding Protein II [英文释义] A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY,OCULOPHARYNGEAL. |
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