| 单词 | PP2B |
| 释义 | PP2B《英文MSH词典》PP2B [同义词] PP2B [主题词] Calcineurin [英文释义] A calcium- and calmodulin-binding protein present in highest concentrations in the central nervous system. Calcineurin is composed of two subunits. A catalytic subunit,calcineurin A,and a regulatory subunit,calcineurin B,with molecular weights of about 60 kD and 19 kD,respectively. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones,myosin light chain,and the regulatory subunit of cAMP-dependent protein kinase. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes in T-lymphocytes that act by inhibiting T-cell activation. EC 3.1.3.-. |
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