| 单词 | Progressive Multifocal Leukoencephalopathies |
| 释义 | Progressive Multifocal Leukoencephalopathies《英文msh词典》Progressive Multifocal Leukoencephalopathies [入口词] Progressive Multifocal Leukoencephalopathies [主题词] Leukoencephalopathy,Progressive Multifocal [英文释义] An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g.,ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes,resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits,generally progressing to a vegetative state within 6 months. (From Joynt,Clinical Neurology,1996,Ch26,pp36-7) |
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