《英文msh词典》Protein Deacetylases,NAD-Dependent
[入口词] Protein Deacetylases,NAD-Dependent
[主题词] Sirtuins
[英文释义] A homologous family of proteins that includes the NAD-dependent protein deacetylases which deacetylate proteins by catalyzing the formation of O-acetyl-ADP-ribose from the ADP-RIBOSE moiety (of NAD) and the acetyl group that is being removed from the protein. Sir2p,from Saccharomyces cerevisiae,is the founding member and the family includes other homologs (HSTs - homologs of Sir Two). Some HISTONE DEACETYLASES (the Sir2-like HDACs) belong to this family of proteins.