《英文msh词典》Pyrophosphorylase,IMP
[入口词] Pyrophosphorylase,IMP
[主题词] Hypoxanthine Phosphoribosyltransferase
[英文释义] An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine,guanine,or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME,while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.