《英文msh词典》Receptor,Baclofen
[入口词] Receptor,Baclofen
[主题词] Receptors,GABA-B
[英文释义] Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and influence cells via interactions with G-proteins. GABA-B receptors are pharmacologically characterized by their insensitivity to the blocker bicuculline and sensitivity to the agonist L-baclofen. They are found both presynaptically and postsynaptically,and act variously by inhibition of adenylate cyclase,activation of phospholipase A2,activation of potassium channels,and inactivation of voltage-activated calcium channels.