单词 | Receptors,Cell Adhesion Protein |
释义 | Receptors,Cell Adhesion Protein《英文msh词典》Receptors,Cell Adhesion Protein [入口词] Receptors,Cell Adhesion Protein [主题词] Integrins [英文释义] A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT,and other cells,while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS,CYTOADHESIN),the leukocyte adhesion receptors (RECEPTORS,LEUKOCYTE ADHESION),and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes,including embryological development,HEMOSTASIS,THROMBOSIS,WOUND HEALING,immune and nonimmune defense mechanisms,and oncogenic transformation. |
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