| 单词 | Region,Bay |
| 释义 | Region,Bay《英文msh词典》Region,Bay [入口词] Region,Bay [主题词] Bay Region (Chemistry) [英文释义] An indentation of three fused benzene rings. A common bay region is the site on BENZO(A)PYRENE,an indirect carcinogen that is metabolically activated by the P-450 system at the 7,8-double bond,leading to a 7,8-oxide,which is rapidly converted to a 7,8-dihydrodiol and later epoxidated near the bay region at the 9,10-double bond. The resulting product,a diol-epoxide is a poor substrate for epoxide hydratase and is released from the mitochondria into the cell as a highly reactive electrophil,becoming an 'ultimate' carcinogen,as it reacts with negative charges in DNA. (From Segen,Dictionary of Modern Medicine,1992) |
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