单词 | 25 Hydroxyvitamin D3 1 alpha Hydroxylase |
释义 | 25 Hydroxyvitamin D3 1 alpha Hydroxylase《英文msh词典》25 Hydroxyvitamin D3 1 alpha Hydroxylase [入口词] 25 Hydroxyvitamin D3 1 alpha Hydroxylase [主题词] 25-Hydroxyvitamin D3 1-alpha-Hydroxylase [英文释义] A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme,encoded by CYP27B1 gene,converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol). |
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