《英文msh词典》Steroid 17 alpha-Monooxygenase
[同义词] Steroid 17 alpha-Monooxygenase
[主题词] Steroid 17-alpha-Hydroxylase
[中文释义] 甾类17α-单加氧酶
[英文释义] A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme,encoded by CYP17 gene,generates precursors for glucocorticoid,androgen,and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA,CONGENITAL) and abnormal sexual differentiation.