| 单词 | Syndrome,Hutchinson-Gilford |
| 释义 | Syndrome,Hutchinson-Gilford《英文msh词典》Syndrome,Hutchinson-Gilford [入口词] Syndrome,Hutchinson-Gilford [主题词] Progeria [英文释义] An abnormal congenital condition,associated with defects in the LAMIN TYPE A gene,which is characterized by premature aging in children,where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors,especially SARCOMA. |
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