| 单词 | Wermer Syndrome |
| 释义 | Wermer Syndrome《英文msh词典》Wermer Syndrome [同义词] Wermer Syndrome [主题词] Multiple Endocrine Neoplasia Type 1 [中文释义] Wermer综合征 [英文释义] A rare syndrome characterized by hyperplasia and/or neoplasms of the pituitary,parathyroid glands,and pancreatic islets. Hyperparathyroidism occurs in 90% of the cases and is usually the first manifestation of the syndrome. The most frequent pancreatic manifestation is gastrinoma typically leading to Zollinger-Ellison Syndrome. The appearance of this condition has been limited to the loss of allelic heterozygosity at the 11q13 locus on the long arm of chromosome 11. Patients overall exhibit long survival times. Chemotherapy is rare and surgical management is generally dependent on the genetic expression in individual patients. (From Holland et al.,Cancer Medicine,3d ed,pp1169-72) |
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