《英文msh词典》11beta Hydroxysteroid Dehydrogenase Type 2
[入口词] 11beta Hydroxysteroid Dehydrogenase Type 2
[主题词] 11-beta-Hydroxysteroid Dehydrogenase Type 2
[英文释义] An high-affinity,NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts undirectionally to catalyze the dehdrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed,APPARENT MINERALOCORTICOID EXCESS SYNDROME.