| 单词 | 12-alpha-Hydroxylase |
| 释义 | 12-alpha-Hydroxylase《英文msh词典》12-alpha-Hydroxylase [同义词] 12-alpha-Hydroxylase [主题词] Steroid 12-alpha-Hydroxylase [英文释义] A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme,encoded by CYP8B1gene,converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol. |
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