| 单词 | Complexes,Ubiquitin-Protein Ligase |
| 释义 | Complexes,Ubiquitin-Protein Ligase《英文msh词典》Complexes,Ubiquitin-Protein Ligase [入口词] Complexes,Ubiquitin-Protein Ligase [主题词] Ubiquitin-Protein Ligase Complexes [英文释义] Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES),conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES),and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES). |
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