单词 | Cytochrome P-450(17 alpha) |
释义 | Cytochrome P-450(17 alpha)《英文msh词典》Cytochrome P-450(17 alpha) [同义词] Cytochrome P-450(17 alpha) [主题词] Steroid 17-alpha-Hydroxylase [英文释义] A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme,encoded by CYP17 gene,generates precursors for glucocorticoid,androgen,and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA,CONGENITAL) and abnormal sexual differentiation. |
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