《英文msh词典》Cytochrome P-450 CYP21
[同义词] Cytochrome P-450 CYP21
[主题词] Steroid 21-Hydroxylase
[英文释义] An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme,encoded by CYP21 gene,converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA,CONGENITAL).