| 单词 | ddI (Antiviral) |
| 释义 | ddI (Antiviral)《英文msh词典》ddI (Antiviral) [同义词] ddI (Antiviral) [主题词] Didanosine [药动学] Reverse Transcriptase Inhibitors [英文释义] A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication,acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate,its putative active metabolite. |
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